Acute Renal Failure and Hemolytic Uremic Syndrome in Overdose With N-acetyl Cysteine After Acetaminophen Poisoning

Context: Acetylcysteine is an effective treatment for acetaminophen poisoning. The preparation and dose calculation of acetylcysteine associated with medical errors. prevalence this error 34% globally. Case report: A 15-year-old girl took overdose in a suicide attempt. intravenous was ordered. Due to the medication by nurse, she received 10-fold both initial loading maintenance dose, at first day. On second day, patient showed abdominal pain, nausea, vomiting, elevated liver enzymes. Her hemoglobin, hematocrit, platelet quickly decreased. Subsequently, developed oliguria, anuria, rising serum creatinine levels. diagnosed uremic hemolytic syndrome. She underwent hemodialysis treated plasmapheresis, blood transfusions, platelets. Discussion: effects poisoning may be much more severe have greater impact on survival than each alone. Timely accurate measures can help prevent long-term side effects.